Fields of Expertise - Bicoll GmbH

Proven Experience

Bicoll’s plant-based small molecule libraries have been proven in the following fields as documented by peer-reviewed published results and patents:

Pharmaceuticals

Antiviral Compounds

The research in this field has been done in the collaboration with HMGU Munich.
Additional publications are in press.

2020: Potent inhibition of HIV replication in primary human cells by novel synthetic polyketides inspired by Aureothin
2016: Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins

Antiepileptic Compounds

2018: Bicoll small molecule has anti-convulsant activity in models of epilepsy
2016: MicroRNAs in Epilepsy: Phatophysiology and Clinical Utility
2013: EpimiRNA – EU Consortium

Anti-Cancer Compounds

2005: German Patent No.10 2005 027 796

Cardiovascular Disorders

2011: The joint project at the forefront of drug discovery and development, focusing on the early diagnosis and preventive treatment of cardio metabolic and associated disorders

Orphan Targets

2013: A fast small molecule ligand validation method for orphan targets
2013: Journal of Biomolecular Screening, Jul 2013, DOI: 10.1177/1087057113497095

Nutraceuticals

Sugar Reduction

2020: Identification of plant derived compounds that function as a tool for sugar reduction
2019: Taste active components in plants identified by data-mining of Chinese historic manuscripts, 12th Wartburg Symposium on Flavor Chemistry & Biology

TASTE MODULATION

2018: World Patent on taste modulating flavoring substances WO2018233841 (A1)

ANTI-INFLAMMATORY

2015: Evaluation of anti-inflammatory and into-oxidative potential of four fern species in Natural Product Communications
2011: Joint project on the development of innovative and qualified botanical ingredients for food and nutraceutical applications aiming to prevent disorders that contain an inflammatory component

Crop Science

Project with Bayer Crop Science

Since 2006 Bicoll has been working together with Bayer Crop Science in the field of crop science. The cooperation is based on the plant expertise of Bicoll and its strong medicinal chemistry knowledge

Working with BASF Crop protection

2004: Synthesis and compounds delivery for BASF in the field of crop protection

Cosmetics

Anti-Inflammatory / AnTi-Oxidative

2015: Anti-inflammatory and antioxidative potential (in cooperation with Naturalpha SAS): Natural product communication

Project with COGNIS France

2004: Confidential results of testing the substances for skin-whitening project with COGNIS France (Laboratories Serobiologiques division)

Collaboration with Stiefel Laboratories

2003: Collaboration with Stiefel Laboratories (now GSK)