Publications Archive

Natural based medicinal chemistry

Medicinal Chemistry & Synthesis: Bicoll seamlessly guides your synthesis and lead optimization projects through drug discovery and development with intensive understanding of structure-activity relationships, capability in biological data
interpretation, solid knowledge of intellectual property and patent aspects. Reliable and fast reporting under your specific requirements. Hit generation speeds up your access to unique sets of compounds …

Plant-based natural products: Most successful source of top 200 pharmaceutical products

Product development candidates into your drug discovery projects: Intelligent screening with Bicoll Profiles™ – innovative techniques, methods and equipment accompanied with the extensive experience and expertise of our scientists in natural product chemistry. Bicoll Plant Profiles™ give you access to the most promising source of new patentable, high quality leads in 9 months at a …

BICOLL NEWS – 2018

Welcome to the 2018 edition of Bicoll News. For those familiar with Bicoll’s previous yearly newsletters, we would like to introduce the good “new-old” style of a snapshot of topics concerning our last year that aims to provide an overview of our services and capabilities. We thank you, our loyal customers, partners and friends for …

Company Teaser in English and Japanese

RELIABLE RESEARCH PARTNER WITH EXPERTISE, KNOW-HOW AND EXPERIENCE IN DRUG DISCOVERY FROM PLANT NATURAL PRODUCTS Read more in a new company teaser 植物天然由来物を用いた創薬における専門知識、 ノウハウ、経験の豊富な信頼できる共同研究パートナー 日本語版はこちらからダウンロードして下さい    

Public impulses to support biotechnology: Healthcare system in China

“Öffentlich getriebene Impulse zur Unterstützung der Biotechnologie”, M. Lamottke, Y. Zhou, “Das Gesundheitswesen in China” Medizinisch Wissentschaftliche Verlagsgesellschaft, 2017, Pp. 165-179 ISBN: 978-3-95466-303-3 „Das Gesundheitswesen in China“ schildert die systembedingten und kulturellen Hintergründe des Umgangs mit Gesundheit und Krankheit. Es zeigt die Zwei-Klassen-Medizin in China als Konsequenz der Wohlstandsunterschiede und des ungleichen Versicherungsschutzes der Patienten. …

MicroRNAs in epilepsy: pathophysiology and clinical utility

Prof. David C. Henshall, Prof. Hajo M. Hamer, MD, Prof. R. Jeroen Pasterkamp, PhD, Prof. David B. Goldstein, PhD, Prof. Jørgen Kjems, PhD, Prof. Jochen H. M. Prehn, PhD, Stephanie Schorge, PhD, Kai Lamottke, PhD, Felix Rosenow, MD, THE LANCET Neurology, Dec. 2016, DOI: http://dx.doi.org/10.1016/S1474-4422(16)30246. Temporal lobe epilepsy is a common and frequently intractable seizure …

Evaluation of the Anti-inflammatory and Anti-oxidative Potential of Four Fern Species from China Intended for Use as Food Supplements

C. Dion, C. Haug, H. Guan, C. Ripoll, P. Spiteller, A. Coussaert, E. Boulet, D. Schmidt, J. Wei, Y. Zhou, K. Lamottke, Natural product communications, 10(4), 597-603, April 2015. Inflammation plays a major role in many diseases, for instance in arteriosclerosis, rheumatoid arthritis, autoimmune disorders and cancer. Since many plants contain compounds with anti-inflammatory activity, …

The Identification of Naturally Occurring Neoruscogenin as a Bioavailable, Potent and High-Affinity Agonist of the Nuclear Receptor RORa (NR1F1)

S. Helleboid, C. Haug, K. Lamottke, Y. Zhou, J. Wei, S. Daix, L. Cambula, G. Rigou, D. W. Hum, R. Walczak, Journal of Biomolecular Screening, Jul 2013, DOI: 10.1177/1087057113497095. New target validation has always been a challenge for the pharmaceutical industry with respect to the potential therapeutic value. Information obtained through genetic gain- and/or loss-of-function …