Hit generation stays in the beginning of lead discovery process. Innovative, fast and flexible access to successful Drug Discovery includes Bicoll qualified drug-like compound library.
1. Intelligent screening
Modern drug discovery campaigns need to include natural products as it enhance the chance to obtain qualified drug-like compounds. Therefore, Bicoll offers its drug-like compound libraryconsists of already fractionated extracts, so called Bicoll Plant . The screening of BILOBAC N provides the initial identification of quality small compounds as lead structures.
Contrary to crude extracts, plant fraction library has reduced complexity of fine fractions. As a result, screening process is easily done with restricted budget and time. Furthermore, Bicoll generates high potential Plant Profiles™ from crude extracts through proprietary separation system.
Bicoll Plant Profiles™ are readily to use in (high-throughput) screening assays. Active agents can be identified within only two rounds of screening. Thereafter, Bicoll performs structure elucidation. Unlike common pure natural product libraries, our technology allows to build up libraries with particular and specific compounds and their novel chemical structures, which were hardly possible to identify from extracts before. Bicoll offers from about 600 compounds from each plant organ. In comparison to expansive pure natural product libraries, structure elucidation is only done for active, interesting and promising compounds. Most elucidated structures range between a molecular weight of 350 to 450. This allows further modification and fine tuning of physiologic parameters (see Lead Generation). – explains Dr. Kai Lamottke, Managing Director.
Above all, intelligent screening with Bicoll Plant Profiles™ saves development time and resources. Furthermore, it provides rich reservoir of structure diversity and high biological activity potential balanced by costs, time and quality.
2. Natural Product Chemistry
Innovative techniques, methods and equipment bring qualified leads into drug discovery projects. Importantly, competitors advantage comes with extensive experience and expertise of Bicoll scientists in natural product chemistry. Therefore, experienced international team provides ideas and services tailored to client specific needs. It includes:
- development of novel deconvolution and isolation strategies to speed up access to unique sets of compounds.
- guarantee rapid structure elucidation to keep projects in time.
- know-how for fast and easy scale up for redelivery of larger compound amounts.
- guidance through all steps of the drug discovery process: From hit generation over Lead Generation to Lead Optimization.